|Журнал: In Proceedings of the 23rd Regional Conference of Dermatology (RCD 2018), pages 485-488||
Allergy Immunology Division, Dermatology Venereology Department, Faculty of Medicine, Universitas Airlangga – Dr.
Soetomo General Hospital, Surabaya, Indonesia.
Medical Student, Faculty of Medicine, Universitas Airlangga – Dr. Soetomo General Hospital, Surabaya, Indonesia.
Allergy Immunology Division, Child Health Department, Faculty of Medicine, Universitas Airlangga – Dr. Soetomo
General Hospital, Surabaya, Indonesia.
Psychoneuroimmunology is an inter disciplinary field that specifically examines the biochemical cross talk
between brain, behavior and the immune system and between allergy immunology concept and psychosocial factors. The increase of allergic manifestation may be associated with environmental factors such as stress. A growing number of studies have suggested an altered hypothalamus-pituitary- adrenal (HPA) axis function to stress in allergy. It is speculated that a dysfunctional HPA axis in response to stress may facilitate and/or consolidate immunological aberrations and thus, may increase the risk for allergic sensitization and exacerbation especially under stressful conditions. It has been established via clinical and physiological means that psychological stress is a significant contributor to allergy course through its direct and indirect effects on immune response, cutaneous neuropeptide expression, and skin barrier function.