|Журнал: Cancers 2021, 13, 4684||Translational Medicine, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada;
School of Medicine, Queen’s University, Kingston, ON K7L 3N6, Canada; Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada;
Defence Research and Development Canada, Toronto Research Centre, Toronto, ON M3K 2C9, Canada;
Faculty of Kinesiology & Physical Education, University of Toronto, Toronto, ON M5S 2W6, Canada
The Psychoneuroimmunology of Stress Regulation in Pediatric Cancer Patients / Gillian E. White, Jessica E. Caterini, Victoria McCann, Kate Rendall, Paul C. Nathan, Shawn G. Rhind, Heather Jones and Greg D. Wells — 2021 y.
There are many commonalities between children with cancer and other populations that experience early-life stress. Thus, it is important to review the existing research surrounding the stress response in the pediatric cancer population. In this review, we describe the psychoneuroimmunology behind stress regulation and the differences observed in stress regulatory pathways in childhood cancer patients.
Our objective is to provide a clinically relevant summary of the stress pathways contributing to, and exacerbating, childhood illness and outline some potential interventions.